UCSD Finds Technique That Could Boost Mapping of Cell Interiors

SAN DIEGO—Using a new artificial intelligence identifying method, researchers at the University of California–San Diego (UCSD) and their collaborators have taken a potentially significant leap forward in understanding human cells, according to a report published in the Nov. 24 issue of “Nature.” The pilot study—which combines microscopy, biochemistry techniques, and artificial intelligence in a technique known as Multi-Scale Integrated Cell (MuSIC)—revealed around 70 components contained within a human kidney cell line, half of which had never been seen before. “If you imagine a cell, you probably picture the colorful diagram in your cell biology textbook, with mitochondria, endoplasmic reticulum, and nucleus. But is that the whole story? Definitely not,” said Trey Ideker, a professor at UCSD’s School of Medicine and Moores Cancer Center. “Scientists have long realized there’s more that we don’t know than we know, but now we finally have a way to look deeper.” In one example, the researchers spotted a group of proteins forming an unfamiliar …

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